2015 Fiscal Year Final Research Report
The inositol prevents occurrence of cleft llip and palate
| Project/Area Number |
25861986
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Toyama (2014-2015)
Aichi Gakuin University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 口唇口蓋裂 / MLPA法 / Prop1 |
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| Outline of Final Research Achievements |
Cleft lip and palate are most frequent congenital anomaly, and the cause elucidation of this anomaly to hold many problems is expected, but there is not a yet definite thing. In the precedent study, the incidence of the cleft palate tended to be prevented by giving Inositol to a mouse.
Therefore, in this study, it was intended to clarify association with Inositol and Wnt signaling. I examined it mainly on connection with PROP1. As a result, I was not able to accept clear gene abnormality by the MLPA method. I did not recognize abnormality about other LHX4, some genes including HESX1 either.
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| Free Research Field |
歯科口腔外科
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