2015 Fiscal Year Final Research Report
Genome-wide association study for abnormal cranio-facial morphology
Project/Area Number |
25861991
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthodontics/Pediatric dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
Saito Fumio 北海道大学, 大学病院, 助教 (00612889)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 歯学 |
Outline of Final Research Achievements |
five loci (1q32.2, 1p22.3, 6q23.2, 7q11.22 and 15q22.22) were likely to be as novel susceptibility regions of mandibular prognathism. PLXNA2, SSX2IP, TARID, CALN1 and RORA genes were considered as a genetic candidate. PLXNA2 gene is a gene encoding semaphorin co-receptors, and the relations to bone metabolism are reported in semaphorin 3A. It has been reported that SSX2IP gene is related to a Synovium Sarcoma and RORA gene has some kind of functions in bone metabolism. We speculate that these genes may be also associated with mandibular prognathism.
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Free Research Field |
医歯薬学
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