Microarray-based analyses of the mechanisms of tooth morphogenesis regulated by IGF-I

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861999
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: CHIDA Toko 東北大学, 大学病院, 助教 (40647947)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 再生医療 / IGF-1 / 歯の形態

Outline of Final Research Achievements

We identified the molecules which are regulated by IGF-I with microarray analysis to clarify the mechanisms of tooth morphogenesis regulated by IGF-I. As a result, IGF-I upregulated expressions of various molecules that modulate tooth development. Moreover, we performed in vivo study to analyze the effects of IGF-I on mice dental mesenchymal cells. IGF-I induced proliferation and differentiation of dental mesenchymal cells.

Free Research Field

医歯薬学