Elucidation of the mechanism of action of estrogen on cartilage destruction of osteoarthritis and its application to diagnostic methods

2016 Fiscal Year Final Research Report

• Project/Area Number: 25862017
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Asakawa-Tanne Yuki (丹根由起) 広島大学, 医歯薬保健学研究院(歯), 助教 (50526241)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 変形性顎関節症 / 下顎頭軟骨 / エストロゲン

Outline of Final Research Achievements

Temporomandibular joint disease is epidemiologically more common in females, and blood estrogen concentrations in patients with temporomandibular disorder are reported to be significantly higher than those in patients without TMJ. Furthermore, since the blood estrogen concentration in patients with osteoarthritis correlates with the pathology of osteoarthritis, it has been suggested that estrogen is deeply involved in the pathogenesis of osteoarthritis. This study revealed that elevated expression of Cox-2 and MMP-3 by high concentration estrogen under conditions loaded with mechanical stretching stimulation is enhanced via the estrogen receptor ERα-NF-KB.

Free Research Field

歯科矯正学