2014 Fiscal Year Final Research Report
Elucidation of multi-directed regulatory mechanism focused on regulation in polycomb genes expression for periodontal cells
| Project/Area Number |
25862049
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 歯周組織再生 / 間葉系幹細胞 / ポリコーム遺伝子 / micro RNA / HIF-1alpha / 歯周靭帯細胞 |
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| Outline of Final Research Achievements |
In this study, it can be suggested that oxygen tension regulate mesenchymal stem cell (MSC) function via hypoxia inducible factor (HIF)-1α, a group of polycomb genes and micro RNA as the expression of polycomb genes were affected by hypoxic condition and hypoxia-induced micro RNA.
Therefore, it is expected that much more effective periodontal regenerative therapy can be come true by the expression regulation of a group of polycomb genes and micro RNA, which controlled by, mainly, control in oxygen tension.
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| Free Research Field |
歯周病学
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