2015 Fiscal Year Final Research Report
Influence on arteriosclerosis by the serum amyloid A isotypic kind
| Project/Area Number |
25862063
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 歯周病 / 動脈硬化症 / ApoE-/-マウス / SAAアイソタイプ / TLR2 |
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| Outline of Final Research Achievements |
The purpose of this study was the pathogenesis elucidation of the mechanism of arteriosclerosis according to another SAA isotype from periodontal disease. As a result of having examined a periodontitis model mouse injected IL-6 to periodontium, quantity of mRNA of SAA1 and SAA2 significantly soared in liver and the lesion. And quantity of mRNA of ICAM-1, VCAM-1, MCP-1, TLR2 developed in the lesion. Furthermore, the aortic lipid deposition was increased. Further, the addition of vascular endothelial cells in SAA1, SAA2, SAA3, when the SAA1 and SAA2, quantity of mRNA of ICAM-1, VCAM-1, MCP-1 and TLR2 was increased significantly.
From the above, possibility of the onset and exacerbation of arteriosclerosis according to another SAA isotype was suggested.
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| Free Research Field |
歯周治療系歯学
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