Structural analysis of HLA-G6 isoform bound to LILRB2 receptor

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870019
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Structural biochemistry; Functional biochemistry
• Research Institution: Hokkaido University
• Principal Investigator: KUROKI KIMIKO 北海道大学, 薬学研究科(研究院), 助教 (90553313)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: HLA-G6 / 電子顕微鏡解析 / 表面プラスモン共鳴法 / CIAマウス

Outline of Final Research Achievements

I performed structural and functional analysis of the HLA-G6 isoform. Electron microscopy technique revealed the three-dimensional structure of HLA-G2/G6 homodimer which resemble HLA class I and HLA class II heterodimer molecule. In addition, I examined the function of HLA-G6 isoform in CIA mice. HLA-G6 specifically bound to the mouse receptor, PIR-B, and showed significant anti-inflammatory effects in vivo.

Free Research Field

生物学