The role of erythropoietin in the production and secretion of neurohypophyseal hormone

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870035
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Integrative animal science; Animal production science
• Research Institution: Iwate University
• Principal Investigator: YAMADA Misuzu (山口美鈴) 岩手大学, 農学部, 准教授 (10414012)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: エリスロポイエチン / 低酸素 / 下垂体ホルモン

Outline of Final Research Achievements

This study revealed that continuous hypoxic stimulation suppressed the water intake and food intake without a decrease in urinary volume. This result indicates that hypoxia disorders the homeostasis of body fluid balance and the regulation of neurohypophyseal hormone. In addition to the constant mRNA expression of erythropoietin（EPO), known as a hypoxia-responsive hematopoietic cytokine, in the neurohypophysis, immunohistochemical analyses detected the expression of EPO receptor in the areas around the inferior hypophyseal artery, where are rich in axon terminals and pituicytes.

Free Research Field

動物生理化学