2015 Fiscal Year Final Research Report
Elucidation of the molecular basis related to the nicotinic acetylcholine receptor involved in the development of oral cancer
| Project/Area Number |
25870047
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ニコチン / 口腔がん / 喫煙 |
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| Outline of Final Research Achievements |
The tobacco is one of the major risk factor for oral cancer. Nicotine is a main component of tobacco, but has not been demonstrated to affect directly carcinogenesis yet. In the present study, nicotine promotes phosphorylation of Epidermal Growth Factor Receptor (EGFR) signal, which pathways associated with mitogenic for cells, also the involvement of nicotinic acetylcholine receptor α7 was suggested.
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| Free Research Field |
病態科学系歯学・歯科放射線学
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