2014 Fiscal Year Final Research Report
Identification and functional analysis of miRNAs that are involved in carcinogenesis of a new molecular subgroup of colorectal cancer
| Project/Area Number |
25870048
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
Tumor diagnostics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 大腸癌 / miRNA / BRAF / CIMP / MSI |
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| Outline of Final Research Achievements |
The aim of this study was to identify specific miRNAs that could be involved in oncogenesis of a molecular subgroup, the MSI/CIMP/BRAF-mutant colorectal cancer, and clarify biological functions of the miRNAs. By using genome-wide miRNA expression analysis, we found some miRNAs specifically dysregulated in BRAF-mutant colorectal cancer, and identified a specific miRNA that acts as a tumor suppressor in colorectal cancer. We further revealed a correlation between the miRNA expression and therapeutic outcome of those who received anti-EGFR therapy. These results suggest that the miRNA contributes to oncogenic process of colorectal cancer, particularly BRAF-mutant cancer, and influences clinical outcome of patients with colorectal cancer. The results could lead to further developing novel targeted therapies of colorectal cancer.
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| Free Research Field |
臨床腫瘍学
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