2014 Fiscal Year Final Research Report
Development of Cell Delivery Carrier Consisting of Free-standing Polymer Nanosheets
| Project/Area Number |
25870050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
Polymer chemistry
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| Research Institution | Waseda University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ナノバイオ材料 / 生体材料科学 / 生体組織工学 / 再生医療 / 細胞移植 / 加齢黄斑変性症 / 高分子超薄膜 / 微細加工技術 |
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| Outline of Final Research Achievements |
For the treatment of intractable retinal diseases such as age-related macular degeneration, in this study we envisioned development of a cell delivery carrier using flexible polymer nanosheets to transplant retinal pigment epithelial cells into a narrow subretinal place. Micropatterned nanosheets were fabricated from poly(lactic-co-glycolic acid), on which the cells were selectively cultured. It was clarified that the engineered cell monolayer on the micropatterned nanosheet was aspirated and injected through a clinical needle without loss of cell viability (approximately 90% viable). The cell monolayer was also transplanted to the subretinal place of rats near the macula. Overall, for the first time we demonstrated the utility of nanosheets in cell delivery system.
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| Free Research Field |
ナノバイオ材料
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