Development of biodegradable antithrombotic biomaterials capable of endothelialization towards resorbable artificial blood vessels

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870078
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Polymer chemistry; Biomedical engineering/Biomaterial science and engineering
• Research Institution: Yamagata University
• Principal Investigator: FUKUSHIMA Kazuki 山形大学, 理工学研究科, 助教 (70623817)
• Research Collaborator: TANAKA Masaru 山形大学, 大学院理工学研究科, 教授 (00322850)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 生分解性ポリマー / 抗血栓性 / 細胞接着性 / 機能性ポリマー / バイオマテリアル

Outline of Final Research Achievements

This study has yielded aliphatic polycarbonates with an ether side chain demonstrating the selective cell adhesive property where little platelets adhere but endothelial cells and smooth muscle cells were adsorbed well. The polycarbonates were also found to be degradable in the presence of lipase. Moreover, a new synthetic route to the cyclic carbonate monomers with functional side chain has been established in the process of developing the new polycarbonates. The antithrombotic polycarbonates can be applied to decreasing hemolytic property of a cationic antimicrobial polycarbonate. These findings will be exploited for further developments of medical devices that require biodegradability, blood compatibility, and cell adhesive property.

Free Research Field

高分子合成、生分解性高分子、バイオマテリアル