2014 Fiscal Year Final Research Report
The Roles of TMEPAI on tumorigenesis
| Project/Area Number |
25870093
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
Tumor biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 腫瘍形成 / TMEPAI / 発現制御 / TGF-beta / EGF |
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| Outline of Final Research Achievements |
TMEPAI is a type I transmembrane protein which is highly expressed in diverse cancer cells. We previously reported that TMEPAI inhibits TGF-b signaling pathway. However, TMEPAI’s role in cancer cell was poorly understood. First, we established TMEPAI knock-down model using lung carcinoma cells, then performed xenograft assay and in vitro sphere formation assay. As a result, Knock-down of TMEPAI significantly reduces lung tumorigenesis emphasizing that autocrine TGF-b is essential for the high expression of TMEPAI in lung carcinoma. Furthermore, EGF signaling collaboratively regulates TGF-b-induced TMEPAI expression. Additionally, C18orf1, a family molecule of TMEPAI, also suppresses TGF-b signaling.
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| Free Research Field |
腫瘍学・分子細胞生物学
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