2014 Fiscal Year Final Research Report
Development of high-sensitive mitochondrial stress reporter for in vivo ROS-damage imaging
| Project/Area Number |
25870118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
Chemical biology
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| Research Institution | Gunma University |
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Principal Investigator |
OIKAWA Daisuke 群馬大学, 生体調節研究所, 助教 (20455330)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 活性酸素 / 炎症シグナル / IL-1β |
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| Outline of Final Research Achievements |
ROS (reactive oxygen species) is a mitochondrial by-product, interfering with various kinds of biomolecule function. In this study, we developed novel reporter systems detecting mitochondrial stress status or inflammatory damage, and evaluated ROS-mediated damage at cellular level or in animal model.
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| Free Research Field |
細胞生物学
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