2014 Fiscal Year Final Research Report
Natural Products Chemical Biology targeting Wnt signaling pathway modulation
| Project/Area Number |
25870128
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
Biomolecular chemistry
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| Research Institution | University of Toyama (2014)
Chiba University (2013) |
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Principal Investigator |
TOUME Kazufumi 富山大学, 和漢医薬学総合研究所, 准教授 (80563981)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 天然物化学 / ケミカルバイオロジー / Wntシグナル |
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| Outline of Final Research Achievements |
In this study, we focused on the Wnt signaling pathway. The Wnt signaling plays pivotal roles not only in various aspects of cell biology and adult tissue homeostasis, but also in various diseases, including cancer. During our screening study targeting Wnt signal, we examined a number of plant and actinomycetes extracts using a cell-based luciferase assay system. As a result, we have isolated and identified a number of bioactive natural compounds that inhibit or enhance Wnt signaling. Molecular-biology investigation of these active compounds revealed that they have various and interesting mode of action.
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| Free Research Field |
天然物化学
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