Search for new risk gene for chronic hepatitis B

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870178
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology; Medical genome science
• Research Institution: The University of Tokyo
• Principal Investigator: SAWAI Hiromi 東京大学, 医学(系)研究科(研究院), 特任助教 (60377124)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 肝臓学 / Ｂ型肝炎 / 疾患関連遺伝子

Outline of Final Research Achievements

We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and their haplotypes with hepatitis B virus infection and healthy control samples among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects. Association analyses identified a new risk allele HLA-DPB1*09:01, and new protective alleles DPB1*02:01 and DPB1*04:01 to chronic HBV infection in addition to the previously reported alleles. Moreover, to identify new host genetic factors contributing to HBV infection, we conducted genome-wide association study (GWAS) and replication analyses using Japanese, Korean, Hong Kong, and Thai individuals. We unfortunately did not replicate the GWAS result although we could identify 529 SNPs with P < 10-4 in the GWAS stage.

Free Research Field

ゲノム医学