Basic studies for the development of bone and periodontal regeneration system using small molecule compounds

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870188
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry; Bioorganic chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: YONEZAWA Takayuki 東京大学, 工学(系)研究科(研究院), 特任助教 (20410665)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 歯周病 / 骨芽細胞 / 低分子化合物

Outline of Final Research Achievements

To develop strategies for bone-periodontal tissue regeneration using small-molecule compounds, the mode of action of harmine, which is an activator compound of osteoblast differentiation, was investigated. As a result, we found that BMP, Wnt and Hedgehog pathways are involved in the action of harmine on osteoblast differentiation.

Free Research Field

歯科医用工学・再生歯学