Antiboitics induced renal injury; explanation for the mechanism and strategy for the prevention

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870245
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine; Kidney internal medicine
• Research Institution: Niigata University
• Principal Investigator: AOKI Nobumasa 新潟大学, 医歯学総合病院, 助教 (60646933)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: メガリン / コリスチン / バンコマイシン / 薬剤性腎障害

Outline of Final Research Achievements

Multidrug-resistant organisms become more problematic worldwide. Although vancomycin and colistin has been key drug against these infections, their nephrotoxicity limited clinical efficacy. We focused on the transporter of proximal renal tubule and analyzed the mechanism responsible for the development of renal involvement. Megalin was identified as a target molecule of the nephrotoxicity through experiments with knock-out mouse and QCM (quartz crystal microbalance). Megalin ligand antagonist was also detected. Megalin ligand antagonist reduced renal damage in mouse model, and held the promise of treating drug-induced renal impairment.

Free Research Field

感染症