Development of biomimetic fiber with molecular alignment and its application to tissue engineering

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870272
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering; Biofunction/Bioprocess
• Research Institution: University of Fukui
• Principal Investigator: Fujita Satoshi 福井大学, 工学(系)研究科(研究院), 准教授 (60504652)
• Research Collaborator: SUYE Shin-ichiro ; MATSUMURA Kazuaki ; SAKAMOTO Hiroaki ; BATNYAM Onon ; NISHIMOTO Shohei
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ナノファイバー / 間葉系幹細胞 / コラーゲン / エレクトロスピニング / 造血幹細胞 / 高密度培養 / 幹細胞ニッチ

Outline of Final Research Achievements

To apply nanofibers to three-dimensional tissue constructs, we have tried to develop nanofiber-based scaffolds, including the self-organization and alignment of pepitide molecules in nanofibers and the stem cell culture by using nanofiber scaffolds. We have successfully fabricated collagen gel-like fibers by exploiting core-shell nanofibers. We also developed culture sheets construct by layering alined fiber sheets and applied them to hemetopoitic stem cell culture, which is called as 'biomimetic fibers'.

Free Research Field

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