Studies on the functional molecular mechanisms of protein components at the ribosomal GTPase-associated center

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870287
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Molecular biology; Applied biochemistry
• Research Institution: Shinshu University
• Principal Investigator: NOMURA Takaomi 信州大学, 学術研究院繊維学系, 助教 (90362110)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: リボソーム / GTPaseセンター / GTPase翻訳因子 / ストークタンパク質 / L11/eL12 / 生物界特異性

Outline of Final Research Achievements

We proposed that the biological and functional significances for the multiple copies of ribosomal stalk protein lie in the efficient assembly of the stalk proteins into the ribosomal particles and the enhancement of the translation rate related to the interaction with GTPase translational factors. Furthermore, we revealed that the C-terminal domain of the stalk protein is a crucial structural element, although L11 (eL12) also acts in coordinated manner, for kingdom-dependent specificity of the ribosome-GTPase translational factor interaction.

Free Research Field

分子生物学