Analysis of phospholipid-transport mechanism between mitochondria and the endoplasmic reticulum

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870311
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional biochemistry; Structural biochemistry
• Research Institution: Nagoya University
• Principal Investigator: TAMURA Yasushi 名古屋大学, 物質科学国際研究センター, 准教授 (50631876)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ミトコンドリア / リン脂質輸送

Outline of Final Research Achievements

Characteristic functions of membrane-bound structures (organelles) in cells are essential for vital activities. Proper phospholipid composition of mitochondrial membranes is required for optimal mitochondrial functions.
In this study, we identified a gene encoding a mitochondrial protein, which genetically interacts with UPS1 as a novel factor involving in phospholipid transport. In addition, by biochemical analyses using recombinant Ups1, we revealed that dynamic interactions between Ups1 and Mdm35 are important for phospholipid transport. These findings would help our understandings in mechanisms of phospholipid transport as well as mitochondrial biogenesis.

Free Research Field

分子細胞生物学