2014 Fiscal Year Final Research Report
Screening for novel therapeutic target molecule focused on the aberrant epigenetic gene regulation in renal cell carcinoma.
| Project/Area Number |
25870348
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 腎細胞癌 / エピジェネティクス |
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| Outline of Final Research Achievements |
The aim of this project is that the screening and validation of the novel target molecule based on the results of gene mutation analysis in renal cell carcinoma (RCC). Using first screening we found some epigenetic related genes as useful candidate target genes. Moreover, the shRNA for these candidate genes inhibited cell growth significantly in VHL gene mutant cells in vitro second screening, and showed same results in vivo.
These results suggested that these candidate target genes are anticipated as the novel target molecule in RCC and the screening methods used in this project is useful.
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| Free Research Field |
分子腫瘍学、分子標的治療学
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