Biomolecule-responsible nanocomposite for DDS application

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870366
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nanomaterials chemistry; Physical pharmacy
• Research Institution: Kyoto University
• Principal Investigator: HASHIDA Yasuhiko 京都大学, 物質-細胞統合システム拠点, 研究員 (30512462)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: カーボンナノチューブ / ドラッグデリバリー / 放出制御 / 薬物キャリア / 酸化還元酵素 / ペプチド / ナノ材料

Outline of Final Research Achievements

To demonstrate the concept of drug release using oxidation-reduction reactions, the model drug-carrier conjugate was prepared and evaluated the release of the model drug. The carbon nanotubes/peptides composite and fluorescein were used as a model drug carrier and a model drug, respectively, and were conjugated via disulfide bond. This conjugate released fluorescein through the disulfide cleavage induced by bioreductive compounds such as reduced glutathione. The possibility that the drug release might be controlled by oxidoreductases was also suggested.

Free Research Field

農学