Self-curing carbonate apatite cement for bone tissue regeneration

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870392
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering; Dental engineering/Regenerative dentistry
• Research Institution: Kyushu University
• Principal Investigator: Toita Riki 九州大学, 歯学研究科(研究院), 助教 (40611554)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 炭酸アパタイト / セメント / 骨補填材

Outline of Final Research Achievements

Hydroxyapatite (HAp) cement is a clinically applicable bone substitute having excellent osteoconductivity. In this study, we found that surface of HAp cement became carbonate apatite (CAp), a bone-like component, after setting, and thus could be replaced by new bone. Upon this result, we tried to create a new CAp cement, where CAp was formed during setting reaction. Calcium carbonate is one of the powder component in CAp cement, and has three polymorphisms, including calcite and vaterite. Vaterite has larger solubility than calcite. CAp cement containing vaterite showed shorter setting time and greater conversion rate to CAp than that containing calcite. Most importantly, CAp cement showed greater osteoconductivity than that of HAp cement CAp cement having excellent osteoconductivity, bioresorbability, and easy morphogenesis would be expected as a new bone substitute that overcome problems of traditional HAp cement.

Free Research Field

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