2015 Fiscal Year Final Research Report
On the novel mathematical modeling framework of cells based on their heterogeneity
| Project/Area Number |
25870396
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
Life / Health / Medical informatics
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| Research Institution | Osaka University |
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Principal Investigator |
Teraguchi Shunsuke 大阪大学, 免疫学フロンティア研究センター, 特任助教 (00467276)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 数理モデル / 機械学習 / シミュレーション / 免疫システム |
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| Outline of Final Research Achievements |
In this research, we have mathematically developed new methodology to perform simulation of cells to increase the applicability of our method. With the help of newly developed approximation and a fast simulator, we constructed a system to identify simulation models from real data automatically. In addition, by applying our framework, we developed a mathematical model of antigen presentation of immune cells to understand the balance between immune tolerance and autoimmune reaction.
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| Free Research Field |
システム生物学
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