Optimization of interfaces between metallic implants and tissues by nano structure formation and surface treatment

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870410
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Composite materials/Surface and interface engineering; Structural/Functional materials
• Research Institution: Osaka University
• Principal Investigator: MIYABE Sayaka 大阪大学, 工学(系)研究科(研究院), 助教 (50584132)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 生体材料 / インプラント / 表面改質 / ナノチューブ / DDS / 金属材料 / 陽極酸化 / 生体親和性

Outline of Final Research Achievements

In this study, I tried the optimization of interfaces between metallic implants and tissues by nano structure formation and surface treatment. Specifically, two types of surface treatments were carried out. One is hydroxyapatite coating by cathodic deposition on self-assembled nanopores on type 316L stainless steel formed by anodic polarization to improve bone compatibility. The other is drug induction to TiO2 nanotube with self-assembled tapered structure for LDDS (Localized Drug Delivery System).
Regardless of the surface shapes (with/without nanopores), needle-like depositions were observed. The depositions were identified as carbonate containing apatite by XRD and FT-IR analysis.
In the drug release test, TiO2 nanotube with self-assembled tapered structure reduced initial burst release rate than conventional TiO2 nanotube formed at 60 V. It is suggested that TiO2 nanotube with self-assembled tapered structure is useful to control drug release for drug delivery system.

Free Research Field

生体材料学