Downstream target genes of a cancer-related transcription factor NAC1 in pancreatic cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870450
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery; Tumor biology
• Research Institution: Shimane University
• Principal Investigator: NISHI Takeshi 島根大学, 医学部, 特別協力研究員 (80538893)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 膵がん / がん関連転写制御因子 / NAC1 / 細胞浸潤能

Outline of Final Research Achievements

NAC1 is a transcription factor that belongs to the BTB/POZ domain family. We reported that low expression of NAC1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma. In this study, we elucidated that 1) NAC1 binds DNA through its BEN domain, 2) identification of the consensus DNA-binding sequence of NAC1, and 3) NAC1 forms a nuclear protein complex capable of modulating gene expression with an apparent molecular weight of 350-450 kDa.
To conquer pancreatic cancer, further analysis requires to find out true downstream genes of NAC1.

Free Research Field

腫瘍外科