The role of Fibroblast growth factor (FGF) signaling on the novel pharmacological action of antidepressants.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870461
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology; Pharmacology in pharmacy
• Research Institution: Hiroshima University
• Principal Investigator: HISAOKA-NAKASHIMA KAZUE (久岡一恵) 広島大学, 医歯薬保健学研究院, 助教 (20393431)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 抗うつ薬 / 神経栄養因子 / アストロサイト

Outline of Final Research Achievements

In this study, I examined the effect of amitriptyline (a tricyclic antidepressant) on the fibroblast growth factor (FGF) signaling in glia. We reported that the amitriptyline-induced FGF signaling activation following glial cell line derived-neurotrophic factor production is occurred by Gi/o activation (Hisaoka-Nakashima K et al., J Biol Chem 290(22): 13678-13691, 2015). Furthermore, we reported that amitriptyline increases FGF2 mRNA expression through EGR1 production in rat primary cultured astrocytes (Kajitani N et al., J Neurochem 135 (1): 27-37, 2015).

Free Research Field

薬理学