2014 Fiscal Year Final Research Report
Elucidation of memory system preserved in bone marrow in pulmonary fibrosis
| Project/Area Number |
25870463
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
Experimental pathology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 線維化 / 骨髄移植 / 肺線維症 / 間質性肺炎 / 肺障害 |
|---|
| Outline of Final Research Achievements |
We hypothesized that in, patients with pulmonary fibrosis, there exist memory system which accelerate pulmonary fibrosis by reacting with unknown antigen. To prove this, we performed bone-marrow transplantation using healthy and bleomycin-induced pulmonary fibrosis mouse as a donor. As a result, the pulmonary fibrosis induced in recipient mice got worse when bone marrow were transplanted from donor mice with pre-established pulmonary fibrosis. In this system, monocytes lineage in donor mice with pre-established pulmonary fibrosis might play a key role.
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| Free Research Field |
呼吸器内科学
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