Reseach for new therapeutic targets of oxaliplatin-induced peripheral neuropathy

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870496
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology; Pain science
• Research Institution: Kyushu University
• Principal Investigator: KAWASHIRI Takehiro 九州大学, 大学病院, その他 (30621685)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: オキサリプラチン / 末梢神経障害 / 抗がん薬 / 副作用（有害事象） / グルタミン酸

Outline of Final Research Achievements

Oxaliplatin, a key drug for colorectal cancer, causes severe peripheral neuropathy. In our study, repeated treatment of oxaliplatin induces hypomyelination and reduced NRG1 expression in peripheral nerve system in rats. Furthermore, oxaliplatin treatment induced reduction in glutamate transporter GLT1 and increase in glutamate concentration in spinal cord.
These results suggest that the hypomyelination and reduction of NRG1 in peripheral nerve system and the spinal extracellular glutamate concentrations via and down-regulation of GLT-1 might be the new therapeutic targets of oxaliplatin-induced peripheral neuropathy.

Free Research Field

医療薬学　臨床薬理学