2014 Fiscal Year Final Research Report
Establishment of intracellular immunization for the development of influenza-resistant livestock
| Project/Area Number |
25870498
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
Animal production science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | インフルエンザウイルス / 感染抵抗性 / 細胞内抗体 / トランスジェニックマウス |
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| Outline of Final Research Achievements |
To demonstrate antiviral effects of intracellular antibody (intrabody) against internal proteins of influenza A virus in cultured cells and transgenic mice, experimental infections were conducted. In cultured cells expressing intrabody, the propagation of viruses of several subtypes were inhibited. In experimental infections with the mouse-adapted virus, all of transgenic mice expressing intrabody survived during the experimental period. These results indicate that the intrabody is sufficient to confer resistance against influenza A virus infections.
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| Free Research Field |
基礎獣医学
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