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2014 Fiscal Year Final Research Report

Pathophysiology and therapeutic development for bisphosphonate-related osteonecrosis of the jaw

Research Project

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Project/Area Number 25870523
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Pathobiological dentistry/Dental radiology
Research InstitutionNagasaki University

Principal Investigator

KUROSHIMA Shinichiro  長崎大学, 病院(歯学系), 講師 (40443915)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywordsビスフォスフォネート製剤 / 顎骨壊死 / 免疫 / 骨壊死 / マクロファージ / リンパ管内皮細胞
Outline of Final Research Achievements

Bisphosphonate-related osteonecrosis of the jaw (BR-ONJ) mainly occurs following tooth extraction with patients taking oral and/or intravenous bisphosphonates. However, the mechanisms of BR-ONJ is unclear. The aim of this study was to address pathophysiology of BR-ONJ using mouse ONJ model in the combination of intravenous bisphosphonate treatment, chemotherapy and tooth extraction. This model indicated that immune suppression might be associated with BR-ONJ due to some immune-related cells and proteins. This findings may contribute to the development of ONJ therapy.

Free Research Field

口腔外科学

URL: 

Published: 2016-06-03  

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