Effect of CTL responses on control of HIV-1 infection in Japanese individuals carrying HLA-B*35:01

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870552
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine; Virology
• Research Institution: Nippon Veterinary and Life Science University (2014); Kumamoto University (2013)
• Principal Investigator: KOYANAGI Madoka 日本獣医生命科学大学, 公私立大学の部局等, 助教 (00543399)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: HIV / CTL / HLA

Outline of Final Research Achievements

HLA-B*35:01 allele associates with high viral load (VL) in Japanese chronically HIV-1 clade B-infected individuals. We investigated the effect of cytotoxic T cell (CTL) responses to HLA-B*35:01-restricted epitopes on the control of HIV-1 in these individuals. Each CTL response to 4 out of 16 HLA-B*35:01-restricted epitopes was significantly but weakly associated with lower VL. The magnitude and the breadth of those 4 epitopes were significantly associated with lower VL. These results indicate even if the each response showed insufficient control of HIV-1, the multiple CTL responses to HLA-B*35:01-restricted epitopes, synergistically affect on the control of HIV-1 in HLA-B*35:01+ Japanese individuals. We found 2 significant association of the presence of HLA-B*35:01 allele with mutants, however HLA-B*35:01-restricted epitopes specific CTLs show cross-reactive with mutants. Those cross-reactive and WT specific CTLs contribute to the control of WT and mutant HIV-1 replication.

Free Research Field

免疫学