2014 Fiscal Year Final Research Report
The role of microRNA let-7a in systemic sclerosis
Project/Area Number |
25870555
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dermatology
Collagenous pathology/Allergology
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Research Institution | Kumamoto University |
Principal Investigator |
MAKINO Katsunari 熊本大学, 医学部附属病院, 非常勤診療医師 (00433037)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | 全身性強皮症 / マイクロRNA / let-7a / 皮膚線維芽細胞 |
Outline of Final Research Achievements |
In this project, we demonstrated the role of microRNA let-7a against skin fibrosis in systemic sclerosis (SSc). The let-7a was the potent regulator of type I collagen. The let-7a levels in dermal fibroblasts and sera of SSc patients were lower than those in healthy control. This down-regulation of let-7a in SSc led to the overexpression of type I collagen. We confirmed that the improvement of bleomycin-induced dermal thickening by let-7a administration. Investigation of more detailed mechanisms of miRNA-mediated regulation of collagen expression may lead to new therapeutic approach against systemic sclerosis.
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Free Research Field |
皮膚科学
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