Development of subtyping cytomegalovirus using cell tropism and pathogenesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870580
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine; Pathological medical chemistry
• Research Institution: Fukushima Medical University
• Principal Investigator: Ikuta Kazufumi 福島県立医科大学, 医学部, 講師 (60512184)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 先天感染 / サイトメガロウイルス / 単純ヘルペスウイルス

Outline of Final Research Achievements

We performed a basic research aimed to develop the subtyping of cytomegalovirus (CMV) based on its pathogenicity related tropism. Multiple trials were performed by using two herpes simplex virus type 1 strains with difference of sorivudine (BVara-U) sensitivity. Sensorineural hearing loss (SNHL) is often observed in children with congenital CMV infection. We analyzed the CMV infecting site in ears by establishing mouse model of CMV-induced SNHL.

Free Research Field

ウイルス学