2014 Fiscal Year Final Research Report
The association between pentraxin 3 and inflammasome in left ventricular remodeling after myocardial infarction
| Project/Area Number |
25870584
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
Cardiovascular medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
SUZUKI Satoshi 福島県立医科大学, 医学部, 助教 (60536944)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ischemia reperfusion / neutrophils / cardiac remodeling / pentraxin 3 |
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| Outline of Final Research Achievements |
The lack of pentraxin 3 (PTX3) produced from bone marrow-derived cells, but not from cardiac resident cells, contributes to inflammation after myocardial ischemia/reperfusion resulting in the increment of infarct size. PTX3 produced from bone marrow-derived cells has a crucial role for cardiac protection against myocardial ischemia/reperfusion injury via attenuating neutrophil infiltration and reactive oxygen species generation.
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| Free Research Field |
Cardiology
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