Investigation of kisspeptin-regulating mechanism by suckling stimulus

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870621
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including histology/embryology); Obstetrics and gynecology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: YAMADA Shunji 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40454079)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: キスペプチン / 授乳期 / 吸乳刺激 / 生殖内分泌

Outline of Final Research Achievements

Kisspeptin is the head of neural peptide regulating reproductive functions, and the expression is remarkably suppressed by suckling stimulus from pups in lactating mother rats who are inhibited reproductive function. The present project was undertaken to investigate what kind of mechanism does suckling stimulus suppress kisspeptin expression through. The present study demonstrated that calcitonin gene-related peptide (CGRP) in the thalamus and brainstem were increased during lactation and thalamic CGRP neurons were activated by suckling stimulus.

Free Research Field

神経内分泌