The association between endoplasmic reticulum stress in myocardial cells and beta-blockers in the perioperative period of cardiac surgery

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870623
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine; Anesthesiology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Taniguchi Fumika 京都府立医科大学, 医学部附属病院, 専攻医 (40515285)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 心臓血管麻酔 / miRNA / βblocker

Outline of Final Research Achievements

We collected data on the perioperative intra-myocardial microRNA expression level. At the same time, we accumulated patients to obtain data on microRNAs, which had marked effects on intracellular information transmission systems, and subjected the data to multivariable analysis. However, it was difficult to confirm the presence of significant differences, possibly because biases (e.g., preoperative cardiac functions and postoperative complications) were included in our results. Therefore, we are unable to conduct an in vitro study at the present time. As the next step, we will take such biases into account and re-analyze the data.

Free Research Field

心臓血管麻酔