2015 Fiscal Year Final Research Report
Roles of inflammasome in the development of NSAID-induced enteropathy
| Project/Area Number |
25870624
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
Experimental pathology
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| Research Institution | Osaka City University |
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Principal Investigator |
Nadatani Yuji 大阪市立大学, 大学院医学研究科, 後期臨床研究医 (00634007)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 小腸傷害 / インフラマソーム |
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| Outline of Final Research Achievements |
The Aim of this study is to investigate the role of inflammasomes in Non-steroidal anti-inflammatory drugs (NSAIDs) induced enteropathy.
This study showed that the NLRP3 inflammasome-associated IL-1beta plays a critical role in NSAIDs-induced small intestinal enteropathy. In addition, the TLR4 and P2X7 signalings plays an improtant roles in developing this NLRP3 inflammasome associated enteropathy.
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| Free Research Field |
消化器内科学
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