2015 Fiscal Year Final Research Report
Investigation into an immune cell therapy for oral cancer associated with gamma delta T cells and the MICA gene
| Project/Area Number |
25870633
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
Immunology
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | γδT細胞 / 口腔がん / 免疫細胞療法 / MICA遺伝子 |
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| Outline of Final Research Achievements |
γδT cells are lymphocytes responsible for anti-cancer immunity; however, because they only comprise a small percentage of the peripheral blood cells in humans, their anti-tumor action has not been sufficiently demonstrated.
The present study investigated the cytotoxicity of in-vitro cultured γδT cells towards oral cancer cells. The methods and results were as follows: （1) Peripheral blood was cultured and the γδT cells activated using zoledronic acid and IL-2. （2) The cytotoxicity of γδT cells towards oral cancer cells appeared to be related to MICA gene polymorphisms. （3) Combining γδT cells with the molecular targeted drug cetuximab increased their cytotoxicity, suggesting the utility of these agents in immunotherapy.
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| Free Research Field |
免疫学
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