2015 Fiscal Year Final Research Report
New development of pulmonary fibrosis therapy based on pulmonary drug delivery technology with fibrinolysis functions
| Project/Area Number |
25870654
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
Pharmacology in pharmacy
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| Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
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Principal Investigator |
Chono Sumio 北海道薬科大学, 薬学部, 教授 (90347790)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 肺線維症 / 肺線維芽細胞 / ピルフェニドン / bFGF修飾リポソーム / 経気道投与型ドラッグデリバリーシステム / コラーゲン産生 |
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| Outline of Final Research Achievements |
Liposomal pirfenidone as a anti-fibrotic drug formulation was designed and prepared, and its efficacy as a pulmonary drug delivery system for treatment of pulmonary fibrosis was evaluated. Liposomal pirfenidone was efficiently delivered to fibroblasts and it inhibited collagen production in fibroblasts. This study suggests that aerosol-based liposomal pirfenidone is a new therapeutic strategy.
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| Free Research Field |
ドラッグデリバリー
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