2015 Fiscal Year Final Research Report
Development of induced production method for dormant fungal secondary biogenesis by modulating new epigenetic targets
| Project/Area Number |
25870660
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomolecular chemistry
Natural medicines
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ケミカルエピジェネティクス / 休眠生合成遺伝子 / 海洋糸状菌 / 二次代謝産物 / 生物活性物質 |
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| Outline of Final Research Achievements |
We have investigated the induced production of new fungal metabolites by modulating new targets of epigenetic factor and several culture methods.
In the course of our studies, the production of a bisabolane sesquiterpene from marine-derived fungus Trichoderma sp. TPU199 was induced using the fermentation with resveratrol as a sirtuin activator. Our continuous efforts revealed that the strain TPU199 had the ability to produce halogenated epidithiodiketopiperazines by the cultivation supplemented with sodium halides. Especially, NaI-added fermentation of the strain TPU199 led to the production of a new iodo derivative, iododithiobrevamide. Moreover, sixteen new metabolites were isolated from the culture broth of six fungal and one actinomycete strains obtained during this study.
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| Free Research Field |
天然物化学
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