2015 Fiscal Year Final Research Report
Relationship of the suppression mechanisum in osteoclasts by IRF-8 and the mechanical stress
| Project/Area Number |
25870674
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
Functional basic dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 破骨細胞 / メカニカルストレス / IRF-8 / NFATc1 |
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| Outline of Final Research Achievements |
In this study, found possibility the osteoclasts responsible for bone resorption in bone metabolism is increase osteoclast differentiation by mechanical stress such as orthodontics. Osteoclast precursor cell-like cells ‘‘RAW264.7 cells’’ was decreased IRF-8mRNA by transiently of mechanical stress and increased NFATc1mRNA . However, After applying transiently mechanical stresses, Increased by IRF-8 with time was supressed osteoclast differentiation .If continuous mechanical stress is applied is considered to NFATc1 in the cytoplasm increases, suggesting that differentiation is easily was enhanced.
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| Free Research Field |
歯科矯正学分野
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