2016 Fiscal Year Final Research Report
Establishment of a rapid method for measuring sphingosine-1-phosphate transporter activity
| Project/Area Number |
25870695
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
Biological pharmacy
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| Research Institution | Setsunan University (2015-2016)
Teikyo Heisei University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 蛍光プレートリーダー |
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| Outline of Final Research Achievements |
Sphingosine-1-phosphate (S1P) is a signal transmitter released from erythrocytes, and essential for migration of lymphocytes to the bloodstream. An S1P transporter, which exports the S1P from erythrocytes to blood plasma, can be considered a potential target for immune-suppressive drugs. In this study, a rapid method to measure the activity of erythrocyte S1P transporter was established. This method is useful for screening of drugs that possess the ability to suppress the activity of the S1P transporter in erythrocytes.
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| Free Research Field |
細胞膜輸送体の機能と生理的役割
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