2014 Fiscal Year Final Research Report
Inhibitors of yellow pigment production by Staphylococcus aureus
| Project/Area Number |
25870704
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
Bioorganic chemistry
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | MRSA / 黄色色素生成阻害剤 / 活性物質 |
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| Outline of Final Research Achievements |
It is well known that S. aureus produces a yellow pigment called staphyloxanthin. Recently, several research groups reported that staphyloxanthin is one of the important virulent factors of S. aureus and the staphyloxanthin biosynthetic pathway of S aureus could be a new potential target to combat MRSA infection. Therefor, we established the screening method and started to find the inhibitors of yellow pigment production. Under this screening, citridone A and graphiumins A to H were found as inhibitors from the culture broth of microorganisms. In the case of citridone A, a common 4,5,6a-trimethyl-4,6a-dihydro-3aH-cyclopentafuran skeleton was necessary to show biological activities.
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| Free Research Field |
天然物化学
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