2016 Fiscal Year Final Research Report
Invention of annulation reaction using alkynyl compounds by metal catalysts
| Project/Area Number |
25870747
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
Organic chemistry
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| Research Institution | Chuo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 不活性結合活性化 / 挿入反応 / 環化反応 / 不飽和結合 / パラジウム / 含酸素環状化合物 |
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| Outline of Final Research Achievements |
Collaboration between oxygen-linked alkynyl group and transition-metal catalysts was found to utilize the straightforward activation of stable carbon-hydrogen bonds in alkynyl-containing organic substrates. This methods were applicable to the activation
of arylic, vinylic, and benzylic carbon-hydrogen bonds followed by intramolecular annulation or intermolecular annulation with other unsaturated bonded compounds via an insertion of the oxygen-bonded alkynyl group. These transformations led to various oxacycles. In addition, we obtained the information about reaction mechanisms, which give us hints to use normal alkynyl groups for carbon-hydrogen bond activation with transition-metal catalysts.
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| Free Research Field |
有機化学
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