2015 Fiscal Year Final Research Report
Molecular mechanisms underlying development and maintenance of thalamic remodeling after peripheral nerve injury
Project/Area Number |
25870757
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology / General neuroscience
Pain science
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Research Institution | Tokyo Women's Medical University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 神経損傷 / 体性感覚 / 視床 / 神経回路 / 軸索 / 可視化 / 受容体 / invivo |
Outline of Final Research Achievements |
Peripheral sensory nerve injury causes reorganization of neural circuitry in the central nervous system as well as abnormal ectopic sensation occasionally resulting in pain. However, although contamination of afferent sensory information has been suggested, concrete neural bases and molecular mechanisms of the pain still remain unknown. In the present study, we focused on remodeling of afferent fibers in the whisker sensory thalamus after peripheral sensory nerve injury and its relationship with abnormal ectopic sensation and molecular bases. We found that new afferent innervations from non-whisker brain stem nuclei to the whisker sensory thalamus after transection of the whisker sensory nerve disrupted somatotopic organization in the thalamus. The large-scale anatomical reorganization spatially and temporally correlated with abnormal ectopic sensations after the injury. Furthermore, thalamus-specific knockout of a specific glutamate receptor inhibited the afferent fiber remodeling.
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Free Research Field |
神経生理学・神経科学一般、疼痛学
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