2015 Fiscal Year Final Research Report
Development of the neuron targeting functional peptide-modified nanocarriers for CNS diseases therapy
| Project/Area Number |
25870767
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
Physical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脳デリバリー / Nose-to-Brain / 機能性ペプチド / 高分子ミセル / ナノキャリア / 核酸デリバリー |
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| Outline of Final Research Achievements |
In this study, to develop the drug/siRNA delivery system to the brain using nasal administration and multifunctional peptide-modified nanocarriers, we designed the novel functional peptide-modified nanocarriers and estimated them about the intracellular siRNA uptake in neuron cells and nose-to-brain delivery of siRNA in rats. The functional peptide-modified nanocarriers strongly increased the intracellular siRNA uptake and siRNA delivery to the brain from nasal cavity. Combination of the funtional peptide-modified nanocarriers and nose-to-brain delivery showed the therapeutic effects in t-MCAO (Transient-Middle Cerebral Artery Occlusion) rats. In conclusion, combination of the funtional peptide-modified nanocarriers and nose-to-brain delivery can be expected as an useful drug delivery system for CNS diseases.
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| Free Research Field |
医療系薬学
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