2015 Fiscal Year Final Research Report
The novel mechanisms of sonic hedgehog gene expression in the chronic inflammation induced cancer
| Project/Area Number |
25870792
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
General medical chemistry
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Abe Yoshinori 日本医科大学, 付置研究所, 助教 (00386153)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | STAT3 / hedgehogシグナル伝達経路 |
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| Outline of Final Research Achievements |
Lung cancer is the most leading cause of cancer death. We found that the expression of sonic hedgehog (Shh) gene, which is a ligand required for hedgehog signaling pathway activation was enhanced in lung cancer-derived cell lines.
From subsequent analysis, we found that a transcription factor STAT3, which is involved in the chronic inflammation-induced tumorigenesis, induced Shh gene expression in lung cancer-derived cell lines. This mechanism may play an important role in tumor maintenance.
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| Free Research Field |
分子生物学
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