2014 Fiscal Year Final Research Report
Functional analysis of Sortilin in innate immune cells
| Project/Area Number |
25870851
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
General medical chemistry
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 自然免疫 / サイトカイン |
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| Outline of Final Research Achievements |
Plasmacytoid dendritic cells (pDCs) are bone marrow-derived cells that sense viruses through Toll-like receptor 9 (TLR9) and TLR7, and secrete large amounts of type I interferon (IFN) in response to viruses. It is known that abnormal activation of pDCs causes several human pathologies, such as systemic lupus erythematosus. Here we report that Sortilin functions as cytokine carrier in pDCs. Knockdown of Sortilin in pDC indicated reduction of IFN-α secretion, while IFNA2 transcription activity was not influenced by knockdown. Our findings suggest that Sortilin is involved in exocytic trafficking of IFN-α in pDC.
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| Free Research Field |
機能生物化学
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